Protein Details: Gap junction alpha-8 protein

Protein ID

ICDB_Pro_0548

Protein Name

Gap junction alpha-8 protein

Gene Name

GJA8

Organism

Homo sapiens (Human)

Length

433 amino acids

AlphaFoldDB

AF-P48165-F1-model_v4.pdb

Function

Sequence

MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Cataract 1;Multiple Types and Cataract-Microcornea Syndrome

Location

Eye lens

DOI ID

10.3109/02713689509033517; 10.3109/02713689508995138; 10.1038/nature04727; 10.1086/301762; 10.1007/s004399900094; 10.1034/j.1399-0004.2001.600614.x; 10.1136/jmg.40.11.e124; 10.1136/bjo.2005.075184; 10.1136/jmg.2005.034108; 10.1136/jmg.2007.051029; 10.1167/iovs.08-3149; 10.3109/13816810.2010.535886; 10.1007/s00439-013-1289-0; 10.3892/mmr.2015.3819; 10.1534/g3.117.300109; 10.1159/000471992; 10.3389/fcell.2022.794837

RefSeq

NP_005258.2; XP_011507718.1